Rams vs 49ers Prediction: Odds, Picks & Betting Preview Week 2 – September 17, 2023

httpscdn.dataskrive.comapiassetHjctLeg Betsperts Media & Technology

Two NFC West foes clash on Sunday, September 17, 2023 at SoFi Stadium when the San Francisco 49ers (1-0) and the Los Angeles Rams (1-0) square off.

49ers vs. Rams Odds

Point Spread

The spread for this matchup is set at 7.5 points, with sportsbooks listing the 49ers as the favorites.

Moneyline

As for the moneyline, the 49ers have -345 odds to pick up the win, while the Rams are listed at +275 to claim victory.

Over/Under

Finally, the total for the game is set at 44.5 points.

BetMGM NFL Promo
NFL First Bet Offer up to $1,000

Game Info

How to Watch 49ers vs. Rams Live?

  • Game Day: Sunday, September 17, 2023
  • Game Time: 4:05 PM ET
  • TV Channel: FOX
  • Location: Inglewood, California
  • Stadium: SoFi Stadium

Betting Preview

49ers

The 49ers averaged 3.9 more points scored last year (26.5) than the Rams allowed (22.6). In games where the 49ers scored more than 22.6 points last season, they were 10-1 overall and 9-2 against the spread.

The 49ers’ offense averaged 365.6 yards per game last season, 24.5 more than the 341.1 the Rams’ defense allowed. The 49ers earned 5.9 yards per play, while the Rams allowed 5.5.

When the 49ers offense put together a game with more than the Rams’ average yardage allowed (341.1) last year, they were 10-2 overall and 8-4 against the spread.

FanDuel NFL Promo
Bet $5, get $200 in bonus bets + $100 off NFL Sunday Ticket!

Rams

The Rams’ average points scored last year (18.1) and the 49ers’ average points allowed (16.3) were within 1.8 points of each other. The Rams were 5-3 overall and 5-3 against the spread when they scored over 16.3 points last season. The Rams’ offense gained 280.5 yards per game last season, 20.1 yards fewer than the 300.6 surrendered by the 49ers’ defense. The Rams accumulated 4.8 yards per play, while the 49ers allowed 5.0.

In contests when the Rams offense accumulated more than the 49ers’ average yard allowance last season (300.6), the team was 4-3 against the spread and 4-3 overall.

DraftKings NFL Promo
NFL Bet $5, Get $200 in Bonus Bets

49ers vs. Rams Injury Report

49ers

Player Pos. Injury Status

Rams

Player Pos. Injury Status
Stetson Bennett QB Shoulder Questionable

49ers vs. Rams Betting Analysis

49ers Betting Insights

Caesars NFL Promo
$1,250 first bet, reward credits, plus bonus bets on the NFL

The 49ers’ record against the spread last year was 11-6-0. Against the spread, as 7.5-point favorites or more, the 49ers went 5-2 last year.

In 17 49ers games last season, nine hit the over.

Rams Betting Insights

Against the spread, the Rams were 6-9-2 last year. The Rams were winless ATS (0-1-1) when playing as at least 7.5-point underdogs last year.

Last season, Los Angeles won two out of the 11 games, or 18.2%, in which it was the underdog. Last season, Los Angeles was at least a +275 underdog on the moneyline two times, losing each of those contests. In 17 Rams games last season, six of them went over the total.

The Rams were underdogs in 11 games last season and won two (18.2%) of those contests. Last season, the Rams were at least a +275 underdog on the moneyline two times, losing each of those contests.

49ers vs. Rams Against The Spread & Betting Records

49ers

Overall Home Away
Point Total AVG 42.2 42.3 42.2
Implied Team Total AVG 23.9 24.2 23.5
ATS Record 11-6-0 7-2-0 4-4-0
Over/Under Record 9-8-0 5-4-0 4-4-0
Moneyline Favorite Record 12-3 8-0 4-3
Moneyline Underdog Record 1-1 0-1 1-0

Rams

Overall Home Away
Point Total AVG 42.2 42.1 42.4
Implied Team Total AVG 23.9 23.8 24.1
ATS Record 6-9-2 4-5-0 2-4-2
Over/Under Record 6-11-0 5-4-0 1-7-0
Moneyline Favorite Record 3-3 2-3 1-0
Moneyline Underdog Record 2-9 2-2 0-7

Players to Watch

49ers

  • Last season over 17 games, Christian McCaffrey racked up 1,139 rushing yards (eighth in the NFL) and scored eight rushing touchdowns. He averaged 67.0 yards per game and 4.7 per carry (18th in the NFL).
  • McCaffrey also was a piece of the passing game with 741 yards (43.6 per game) on 85 receptions (5.0 per game), while being targeted 108 times. He had five receiving touchdowns.
  • Brandon Aiyuk had 78 catches for 1,015 yards and eight receiving touchdowns. He was targeted 114 times and averaged 4.6 receptions per game over 17 games played.
  • George Kittle put up 765 receiving yards and 11 touchdowns (third in the NFL) on 60 receptions while being targeted 86 times last year.
  • Deebo Samuel had 56 catches for 632 yards and two receiving touchdowns. He averaged 4.3 yards per game over 13 games and was targeted 94 times.
  • Nick Bosa’s 2022 effort included 51 tackles, 19.0 TFL, and 18.5 sacks in 16 games.
  • Fred Warner had 2.0 sacks to go with 3.0 TFL, 130 tackles, and one interception.
  • Dre Greenlaw recorded 3.0 TFL, 127 tackles, and one interception in the 2022 season.
  • Talanoa Hufanga intercepted four passes to go with 95 tackles, 5.0 TFL, 2.0 sacks, and nine passes defended.

Rams

  • Cam Akers got things done in the ground game last year, rushing for 786 yards and seven touchdowns in 15 games.
  • Matthew Stafford played nine games last season, and tallied 2,087 passing yards, 10 touchdowns, eight interceptions and a 68.0% completion percentage.
  • When he wasn’t airing it out, Stafford scrambled for 9 yards (1.0 yards per game) and one touchdown.
  • Tyler Higbee was a key part of the passing attack last year, accumulating 72 receptions for 620 yards and three touchdowns.
  • Demarcus Robinson was targeted 75 times with the Ravens last year, leading to 48 receptions, 458 yards and two touchdowns in 17 games.
  • John Johnson helped spur the Browns’ defense last year with 96 tackles, 4.0 TFL, 0.5 sacks, and one interception in 17 games.
  • Ernest Jones played in 17 games, posting one interception to go along with 113 tackles, 4.0 TFL, and two passes defended.
  • Aaron Donald totaled 49 tackles, 10.0 TFL, 5.0 sacks, and two passes defended in 11 games.
  • Michael Hoecht was a key player on D last year, with 34 tackles, 4.0 TFL, and 4.5 sacks.

49ers vs. Rams Predictions and Pick

Our pick to win this game is the 49ers, and we predict that Rams will cover the spread (49ers -7.5). Finally, we see the scoring in this one going under the posted total of 44.5 points.

EDGE Boost
Double your next bet at any sportsbook for FREE with EDGE Boost!
Caesars NFL Promo
$1,250 first bet, reward credits, plus bonus bets on the NFL
DraftKings NFL Promo
NFL Bet $5, Get $200 in Bonus Bets
FanDuel NFL Promo
Bet $5, get $200 in bonus bets + $100 off NFL Sunday Ticket!
BetMGM NFL Promo
NFL First Bet Offer up to $1,000

How to Bet on 49ers vs. Rams

You can bet this 49ers vs. Rams pick at every legal online sportsbook

You can check our live NFL lines for the latest NFL odds, including money lines, spreads, and over/under totals.

Tip: If you want to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Rams picks, don’t forget to check out our free parlay calculator.

What is a parlay? Or even how to bet on football? Check out our complete guide to the best NFL betting sites.

Deals of the Day

See All